danazol

What is the most important information I should know about danazol?

You should not use this medicine if you have: undiagnosed vaginal bleeding, porphyria, severe liver or kidney disease, severe heart problems, or if you have ever had a stroke or blood clot, or cancer of the breast, uterus/cervix, or vagina.

What is danazol?

Danazol is used to treat endometriosis.

Danazol is also used to treat attacks of hereditary angioedema (an immune system disorder).

Danazol may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking danazol?

• undiagnosed vaginal bleeding;
• severe heart problems;
• a history of stroke or blood clot;
• severe liver or kidney disease;
• porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); or
• a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.

Tell your doctor if you have ever had:

• heart problems;
• high blood pressure;
• liver disease;
• kidney disease;
• epilepsy or other seizure disorder;
• diabetes; or
• migraine headaches.

You may need to have a negative pregnancy test before starting this treatment.

How should I take danazol?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You will need frequent medical tests.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using danazol.

Women who take danazol to treat endometriosis should start the medication during a menstrual period.

Danazol is usually given for 3 to 9 months to treat endometriosis. To prevent attacks of hereditary angioedema, you may need to use the medication long-term.

Follow your doctor's dosing instructions very carefully.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking danazol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of danazol?

• loss of appetite, stomach pain (upper right side);
• cough with bloody mucus or vomit that looks like coffee grounds;
• jaundice (yellowing of the skin or eyes);
• bloody or tarry stools, dark urine;
• swelling or weight gain;
• a hoarse or deepened voice, sore throat;
• hair loss, or increased hair growth;
• acne or other skin problems;
• unexplained muscle pain, tenderness, or weakness;
• increased pressure inside the skull --severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
• signs of a blood clot --sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.

Common side effects may include:

• flushing (sudden warmth, redness, or tingly feeling);
• changes in your menstrual periods;
• unusual vaginal bleeding or spotting;
• breast changes;
• sexual problems;
• decreased amount of semen released during sex;
• mood changes, nervousness; or
• vaginal dryness or irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect danazol?

Tell your doctor about all other medicines you use, especially:

• carbamazepine;
• cyclosporine;
• tacrolimus;
• warfarin;
• insulin or oral diabetes medications; or
• cholesterol lowering medicines such as atorvastatin, lovastatin, or simvastatin.

This list is not complete. Other drugs may affect danazol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about danazol.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01. Revision date: 1/24/2019.