mefloquine

What is the most important information I should know about mefloquine?

You should not take mefloquine to prevent malaria if you have a recent history of depression, an anxiety disorder, seizures, mental illness (such as schizophrenia), or psychosis.

What is mefloquine?

Mefloquine is a medicine used to treat malaria, a disease caused by parasites. This medicine works by interfering with the growth of parasites in the red blood cells of the human body.

Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

Mefloquine is also used to prevent malaria.

Mefloquine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking mefloquine?

You also should not use mefloquine to prevent malaria if you have a recent history of:

• depression;
• an anxiety disorder;
• seizures; or
• mental illness (such as schizophrenia) or psychosis.

However, your doctor may prescribe mefloquine to treat malaria even if you do have any of the conditions listed above.

To make sure mefloquine is safe for you, tell your doctor if you have:

• heart disease;
• liver disease;
• epilepsy or other seizure disorder;
• diabetes;
• bleeding or blood clotting disorder;
• a history of mental disease; or
• if you take a blood thinner (warfarin, Coumadin, Jantoven).

FDA pregnancy category B. It is not known whether mefloquine will harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medication. Use effective birth control while you are using this medication and for at least 3 months after your treatment ends.

How should I take mefloquine?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

It is important to use this medication regularly (before, during and after travel) to best prevent malaria. If you stop using the medication early for any reason, talk to your doctor about other forms of malaria prevention.

If you have trouble swallowing the mefloquine tablet, you may crush the tablet and mix it into a small glass of milk, water, or other beverage to make swallowing easier.

If you are taking this medicine to prevent malaria:

• Mefloquine is usually taken once per week to prevent malaria.
• Start taking the medicine 1 to 3 weeks before entering an area where malaria is common. Continue taking the medicine once weekly during your stay and for at least 4 weeks after you leave the area.
• Take your weekly dose on the same day each week.
• If you stop taking the medicine early for any reason, contact a healthcare professional about another form of malaria prevention.

If you are taking mefloquine to treat malaria:

• Take as directed by your doctor.

In addition to taking mefloquine, use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria.

If you use this medication long-term, you may need frequent blood tests to check your liver function. Your vision may also need to be checked.

No medication is 100% effective in treating or preventing malaria. For best results, keep using the medication as directed. Talk with your doctor if you have fever, vomiting, or diarrhea during your treatment.

What happens if I miss a dose?

Since mefloquine is often used as a single dose, you may not be on a dosing schedule. If you are on a weekly schedule, use the missed dose as soon as you remember. Then take the next dose on your next usual dosing day. Do not use extra medicine to make up the missed dose.

Call your doctor for instructions if you forget to take the medicine within 1 week before your travel.

What happens if I overdose?

What should I avoid while taking mefloquine?

Avoid taking chloroquine, quinine, or quinidine while you are taking mefloquine.

What are the possible side effects of mefloquine?

• sudden headache, ringing in your ears, dizziness, loss of balance, or problems with coordination;
• severe anxiety, depression;
• paranoia, hallucinations (seeing or hearing things that are not real);
• confusion, unusual behavior; or
• thoughts about suicide or hurting yourself.

• a light-headed feeling, like you might pass out;
• seizure (convulsions);
• increased blood pressure --severe headache, blurred vision, chest pain, shortness of breath, uneven heartbeats; or
• liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• stomach pain, vomiting, diarrhea;
• dizziness;
• muscle pain;
• fever, chills; or
• mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect mefloquine?

Many drugs can interact with mefloquine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with mefloquine, especially:

• heart or blood pressure medication;
• medicine to treat depression or mental illness;
• seizure medication;
• tuberculosis medication; or
• a "live" vaccine such as measles, mumps, and rubella (MMR).

This list is not complete and many other drugs can interact with mefloquine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about mefloquine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 7.01. Revision date: 12/12/2013.