mitomycin
What is the most important information I should know about mitomycin?
Mitomycin can damage red blood cells, which may cause irreversible kidney failure. Tell your doctor right away if you have unusual bruising or bleeding, pale skin, confusion, tiredness or irritability, stomach pain, bloody diarrhea, red or pink urine, swelling, rapid weight gain, and little or no urinating.
Mitomycin can also weaken (suppress) your immune system, and you may get an infection more easily. Call your doctor if you have signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness).
What is mitomycin?
Mitomycin is used in combination with other cancer drugs to treat cancer of the stomach and pancreas.
Mitomycin may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before receiving mitomycin?
You should not be treated with mitomycin if you are allergic to it, or if you have:
- low levels of platelets in your blood;
- bone marrow suppression; or
- active bleeding or any risk of bleeding.
Tell your doctor if you have ever had:
- kidney disease;
- heart disease; or
- asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder.
Mitomycin may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
You should not breastfeed while using mitomycin.
How is mitomycin given?
Mitomycin is given as an infusion into a vein. A healthcare provider will give you this medicine.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when mitomycin is injected.
Some people receiving mitomycin have developed ulcers on the skin where an injection was given, or on other areas of body. Skin changes may occur several weeks or months after a mitomycin injection. Call your doctor if you notice any redness, sores, oozing, or other skin changes during or after your treatment with mitomycin.
Mitomycin affects your immune system. You may get infections more easily. You will need frequent medical tests, and your next dose may be delayed based on the results.
Mitomycin can have long lasting effects on your body. You may also need medical tests for a short time after your last dose.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your mitomycin injection.
What happens if I overdose?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving mitomycin?
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
What are the possible side effects of mitomycin?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Mitomycin can damage red blood cells, which may cause irreversible kidney failure. Tell your doctor right away if you have unusual bruising or bleeding, pale skin, confusion, tiredness or irritability, stomach pain, bloody diarrhea, red or pink urine, swelling, rapid weight gain, and little or no urinating.
Call your doctor at once if you have:
- signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness);
- wheezing, chest tightness, new or worsening cough, trouble breathing;
- blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or
- pain, burning, redness, swelling, irritation, or skin changes where the injection was given.
Common side effects may include:
- fever or other signs of infection;
- nausea, vomiting, diarrhea, loss of appetite;
- mouth sores;
- drowsiness, headache;
- blurred vision; or
- temporary hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect mitomycin?
Other drugs may affect mitomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Where can I get more information?
Your doctor or pharmacist can provide more information about mitomycin.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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