treprostinil (inhalation)

What is the most important information I should know about treprostinil inhalation?

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What is treprostinil inhalation?

Treprostinil is used to treat pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD) in adults. This medicine improves your ability to exercise and can help prevent your condition from getting worse.

Treprostinil may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using treprostinil inhalation?

Tell your doctor if you have or have ever had:

• bronchospasm (wheezing, chest tightness, trouble breathing);
• low blood pressure;
• asthma, COPD, sleep apnea, or other breathing disorder;
• bleeding problems; or
• liver disease.

Tell your doctor if you are pregnant or breastfeeding.

How should I use treprostinil inhalation?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Do not use or mix other medicines with treprostinil inhalation.

Treprostinil inhalation is usually given 4 times per day at evenly spaced intervals during waking hours. Use exactly as directed on the label, or as prescribed by your doctor.

Read and carefully follow any instructions for setting up and using the medicine before preparing your first dose. Ask your doctor or pharmacist if you do not understand these instructions.

The effects of treprostinil inhalation will lessen over time between doses. Talk with your doctor if you need to time your dosing around any planned activities.

Follow all storage and cleaning instructions provided with treprostinil inhalation. Your pharmacist can provide more information about how to store this medicine.

Make sure you have a backup inhalation system available in case one of the systems stops working.

What happens if I miss a dose?

Use the medicine as soon as you can. Do not use two doses at one time.

What happens if I overdose?

Overdose symptoms may include headache, warmth or tingling, vomiting, diarrhea, or feeling light-headed.

What should I avoid while using treprostinil inhalation?

Do not shake or drop the inhaler. Keep inhaler upright with mouthpiece pointing up.

Avoid getting this medicine on your skin. If this medication gets on your skin, wash the area quickly with soap and water.

What are the possible side effects of treprostinil inhalation?

• a light-headed feeling, like you might pass out; or
• easy bruising or bleeding (nosebleeds, bleeding gums).

Common side effects may include:

• cough, pain or irritation in your throat after use;
• dizziness or feeling light-headed;
• nausea, diarrhea;
• headache; or
• flushing (sudden warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect treprostinil inhalation?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect treprostinil inhalation, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about treprostinil inhalation.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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