ranolazine

What is the most important information I should know about ranolazine?

Tell your doctor about all your other medicines. Some drugs should not be used with ranolazine.

What is ranolazine?

Ranolazine is used in adults to treat chronic angina (chest pain). Ranolazine is not for use during an acute (emergency) attack of angina.

Ranolazine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ranolazine?

• cirrhosis of the liver.

• clarithromycin;
• nefazodone;
• St. John's wort;
• antifungal medicine --itraconazole, ketoconazole;
• HIV or AIDS medicine --indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir;
• seizure medicine --carbamazepine, phenobarbital, phenytoin; or
• tuberculosis medicine --rifabutin, rifampin, rifapentine.

Tell your doctor if you have ever had:

• long QT syndrome (in you or a family member);
• liver disease; or
• kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

How should I take ranolazine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take ranolazine tablets with or without food.

Open the pack of ranolazine granules and mix the medicine with a tablespoon of soft food such as applesauce or yogurt. Swallow the mixture right away without crushing or chewing.

Ranolazine granules can also be given through a feeding tube. Ask your doctor or pharmacist if you do not understand these instructions.

Chronic angina is often treated with a combination of drugs. Do not change your dose or dosing schedule without your doctor's advice.

You may need medical tests to check your heart and kidney function.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Overdose symptoms include nausea, vomiting, numbness or tingling, low blood pressure, dizziness, irregular heartbeats, trouble speaking, double vision, hallucinations, confusion, uncontrolled shaking, or fainting.

What should I avoid while taking ranolazine?

Grapefruit may interact with ranolazine and lead to unwanted side effects. Avoid the use of grapefruit products.

What are the possible side effects of ranolazine?

• a light-headed feeling;
• fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or
• kidney problems --swelling, urinating less, feeling tired or short of breath.

Common side effects may include:

• nausea, constipation;
• headache; or
• dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ranolazine?

Tell your doctor about all your current medicines. Many drugs can affect ranolazine, especially:

• any other medicine to treat heart disease;
• an antibiotic or antifungal medicine;
• oral diabetes medicine;
• medicine to prevent organ transplant rejection;
• medicine to treat a mental illness; or
• medicine to treat or prevent nausea and vomiting caused by chemotherapy or radiation.

This list is not complete and many other drugs may affect ranolazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about ranolazine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 12.02. Revision date: 5/23/2023.