eribulin

What is the most important information I should know about eribulin?

What is eribulin?

Eribulin is used to treat breast cancer that has spread to other parts of the body (metastatic).

Eribulin is also used to treat liposarcoma, a rare type of cancer that develops in fatty tissue anywhere in the body. Eribulin is used for liposarcoma that cannot be treated with surgery, or has spread throughout the body.

Eribulin is usually given after at least two other cancer treatments did not work or have stopped working.

Eribulin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving eribulin?

Tell your doctor if you have ever had:

• liver disease;
• kidney disease;
• heart problems;
• long QT syndrome (in you or a family member); or
• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

• If you are a woman, do not use eribulin if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your last dose.
• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3.5 months (14 weeks )after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using eribulin.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because eribulin can harm an unborn baby.

How is eribulin given?

Eribulin is given as an infusion into a vein. A healthcare provider will give you this injection.

Eribulin is given in a 21-day treatment cycle. You may need to use the medicine only during the first 1 to 2 weeks of each cycle. Your doctor will determine how long to treat you with this medicine.

Eribulin can weaken (suppress) your immune system, and you may get an infection or bleed more easily. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

Your heart function may also need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

What happens if I miss a dose?

What happens if I overdose?

Overdose symptoms may include signs of infection such as fever or chills.

What should I avoid while receiving eribulin?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What are the possible side effects of eribulin?

• chest pain, severe dizziness, fast or pounding heartbeats;
• numbness, tingling, or burning pain in your hands or feet;
• pain or burning when you urinate;
• low calcium level --muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes);
• low potassium level --leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
• low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• low blood cell counts;
• low calcium or potassium levels;
• nausea, constipation;
• hair loss; or
• feeling tired or weak.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect eribulin?

Other drugs may affect eribulin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about eribulin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01. Revision date: 9/14/2020.