enzalutamide

What is the most important information I should know about enzalutamide?

What is enzalutamide?

Enzalutamide is used to treat prostate cancer in men who have received surgery or hormone therapy to lower testosterone.

Enzalutamide is sometimes used when the cancer no longer responds to treatment, but has not spread to other parts of the body.

Enzalutamide is also used to when the cancer has responded to treatment and has spread to other parts of the body (metastatic).

Enzalutamide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking enzalutamide?

Tell your doctor if you have ever had:

• a seizure;
• a head injury, stroke, or brain tumor;
• heart disease, circulation problems;
• high blood pressure;
• diabetes; or
• high cholesterol or triglycerides (a type of fat in the blood).

• If your sex partner is pregnant, always use a condom during sex.
• If your sex partner could become pregnant, use effective birth control to prevent pregnancy. Keep using birth control for at least 3 months after you stop taking enzalutamide.
• Tell your doctor at once if a pregnancy occurs while you are taking enzalutamide.

How should I take enzalutamide?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take the medicine at the same time each day, with or without food.

You may need to take 2 to 4 tablets at a time to get a full dose.

Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you forget your dose for the entire day, skip the missed dose and go back to your regular schedule the next day. Do not take two doses in one day.

What happens if I overdose?

What should I avoid while taking enzalutamide?

Enzalutamide can increase your risk of seizure. Avoid any activity that could be dangerous if you have a seizure or lose consciousness.

Even without dizziness, taking enzalutamide could increase your risk of falls or bone fractures. Avoid activities or situations that may lead to injury or falls.

What are the possible side effects of enzalutamide?

• dizziness, spinning sensation;
• a seizure (black-out or convulsions);
• confusion, thinking problems, severe headache, vision problems;
• weakness, loss of consciousness;
• red or pink urine;
• heart problems --chest pain, shortness of breath (even with mild exertion);
• increased blood pressure --severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed; or
• signs of a lung infection --fever, cough with yellow or green mucus, stabbing chest pain, wheezing, feeling short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• feeling weak or tired;
• constipation, diarrhea;
• loss of appetite;
• flushing (redness, hot feeling);
• back pain, joint pain; or
• high blood pressure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect enzalutamide?

Many drugs can affect enzalutamide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about enzalutamide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 5.01. Revision date: 4/2/2021.