nifurtimox

What is the most important information I should know about nifurtimox?

Follow all directions on your medicine label and package. Tell each of your child's healthcare providers about all the medical conditions, allergies, and medicines the child uses.

What is nifurtimox?

Nifurtimox is used to treat Chagas disease, a condition caused by a parasite. Chagas disease occurs most commonly in Mexico, Central America, and South America.

Nifurtimox is for use in children from birth through their 17th year. A child must weigh at least 5.5 pounds (2.5 kilograms) before taking this medicine.

Nifurtimox may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking nifurtimox?

Tell your child's doctor if the child has ever had:

• a brain injury;
• a seizure;
• mental illness or psychosis;
• kidney disease (or if the child is on dialysis);
• liver disease; or
• porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

• If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 6 months after your last dose.
• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
• Tell the doctor right away if a pregnancy occurs.

It may be harder for you to get a woman pregnant while you are using this medicine.

If you are breastfeeding, tell the doctor if you notice symptoms in the nursing baby such as fussiness, decreased appetite, vomiting, rash, or fever.

How should I take nifurtimox?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your child's dose. Take the medicine exactly as directed.

Each tablet should be swallowed whole or split in half. You may split a tablet by breaking it along scored line with your fingertip. Do not split a nifurtimox tablet using a tablet-cutting device.

If the child cannot swallow a tablet whole, place the tablet into 1/2 teaspoon of water. Allow the tablet to completely dissolve (in about 30 seconds). Give the mixture right away with food.

Nifurtimox doses are based on weight and may change if the child gains or loses weight. The doctor should check the child's weight every 2 weeks while the child takes nifurtimox.

Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

What happens if I miss a dose?

Give the medicine as soon as you can, but skip the missed dose if your child's next dose is due in less than 3 hours. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking nifurtimox?

Follow your child's doctor's instructions about any restrictions on food, beverages, or activity.

This medicine may cause muscle weakness or tremors and may impair your child's reactions. Your child should avoid driving or hazardous activity until you know the effects of this medicine.

What are the possible side effects of nifurtimox?

• a decreased appetite and weight loss;
• new or worsening symptoms of a pre-existing condition (such as a brain injury, seizures, behavior changes, or mental health problems); or
• worsening symptoms of porphyria (dark urine, severe stomach pain, muscle pain, numbness, tingling, mental changes, or skin sensitivity to light).

Common side effects may include:

• stomach pain, nausea, vomiting;
• loss of appetite;
• fever;
• rash; or
• headache.

This is not a complete list of side effects and others may occur. Call your child's doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect nifurtimox?

Other drugs may affect nifurtimox, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell the doctor about all other medicines your child use.

Where can I get more information?

Your child's doctor or pharmacist can provide more information about nifurtimox.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 2.01. Revision date: 3/13/2023.