rolapitant (oral)
What is the most important information I should know about rolapitant?
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
What is rolapitant?
Rolapitant is used together with other medicines to prevent nausea and vomiting caused by cancer chemotherapy.
Rolapitant may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking rolapitant?
Some medicines can cause unwanted or dangerous effects when used with rolapitant. Your doctor may change your treatment plan if you also use:
- pimozide; or
- thioridazine.
Rolapitant is not approved for use by anyone younger than 2 years old.
Tell your doctor if you have ever had:
- liver disease; or
- if you use a blood thinner (such as warfarin) and you have routine "INR" or prothrombin time tests.
Tell your doctor if you are pregnant or breastfeeding.
This medicine may affect fertility (your ability to have children) for a short time.
How should I take rolapitant?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Rolapitant is usually given on Day 1 of your chemotherapy treatment.
You may take rolapitant with or without food.
You should not take rolapitant more than once every 14 days.
You will be given other medication to prevent nausea or vomiting. Keep using these medicines for as long as your doctor has prescribed.
Store at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take the medicine.
What happens if I miss a dose?
Call your doctor for instructions if you forget to take the tablets at the correct time before chemotherapy. The timing of your rolapitant dose is important for this medicine to be effective.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid after taking rolapitant?
For at least 1 month after you use rolapitant, avoid using any cough or cold medicine that contains dextromethorphan. Talk to your doctor about how to best treat a cough due to the common cold.
What are the possible side effects of rolapitant?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- pain or burning when you urinate;
- low red blood cells (anemia) --pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
- low white blood cell counts --fever, swollen gums, painful mouth sores, skin sores, cold or flu symptoms, cough, trouble breathing.
Common side effects may include:
- low blood cell counts;
- painful urination;
- mouth sores;
- hiccups;
- dizziness; or
- stomach pain, indigestion, loss of appetite.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect rolapitant?
For at least 28 days after you use rolapitant, it could affect other medicines you are using.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect rolapitant, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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