tivozanib

What is the most important information I should know about tivozanib?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is tivozanib?

Tivozanib is used to treat advanced kidney cancer in adults, after at least two other cancer treatments did not work or have stopped working.

Tivozanib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking tivozanib?

Tell your doctor if you have ever had:

• heart problems;
• high blood pressure;
• a blood clot, heart attack, or stroke;
• bleeding problems;
• surgery, including oral surgery;
• a wound that has not healed;
• a thyroid disorder;
• liver disease; or
• an allergy to aspirin or yellow dye (tartrazine).

You may need to have a negative pregnancy test before starting this treatment.

Keep using birth control for at least 1 month after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using tivozanib.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

How should I take tivozanib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Tivozanib is given in a 28-day treatment cycle. You may need to use the medicine only during the first 21 days of each cycle. Your doctor will determine how long to treat you with this medicine.

You may take tivozanib with or without food.

Your blood pressure will need to be checked often. You may also need blood or urine tests.

If you need surgery or dental work, tell your surgeon or dentist you currently use this medicine. You should stop taking tivozanib for at least 24 days before a planned surgery.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses in the same day.

What happens if I overdose?

Overdose may cause severely high blood pressure.

What should I avoid while taking tivozanib?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of tivozanib?

• severe headache, confusion, dizziness;
• a seizure;
• chest pain, shortness of breath;
• blurred vision, pounding in your neck or ears;
• swelling in your lower legs, rapid weight gain;
• any wound that will not heal;
• easy bruising or bleeding (nosebleeds, bleeding gums);
• signs of bleeding inside your body --weakness, dizziness; pink or brown urine; abnormal vaginal bleeding; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• signs of a blood clot --sudden numbness or weakness on one side of the body, chest pain, problems with vision or speech, pain or swelling in an arm or leg; or
• kidney problems --swelling, puffy eyes, foamy urine.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• nausea, vomiting, diarrhea, loss of appetite;
• feeling weak or tired;
• cough, hoarse voice;
• mouth sores; or
• abnormal blood tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect tivozanib?

Other drugs may affect tivozanib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about tivozanib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 1.01. Revision date: 4/16/2021.