Drug Information
Trazodone is a weak serotonin reuptake inhibitor drug with other effects on brain neurotransmitters. It is used to treat people with depression. It is also used to treat people during cocaine withdrawal.
Common brand names:
DesyrelSummary of Interactions with Vitamins, Herbs, & Foods
Types of interactions:BeneficialAdverseCheck
Replenish Depleted Nutrients
Potential Negative Interaction
Digitalis (Digitalis lanata, Digitalis purpurea) refers to a family of plants commonly called foxglove that contain digitalis glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin.
Trazodone was associated with increased serum digoxin levels in one case report. No interactions between trazodone and digitalis have been reported. Until more is known, trazodone and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
- Ginkgo
There is one case report of an elderly patient with Alzheimer’s disease going into a coma while concurrently using trazodone and ginkgo. Until more is known, ginkgo should not be combined with trazodone except under supervision of a doctor.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
- St. John’s Wort
One report described a case of serotonin syndrome in a patient who took St. John’s wort and trazodone. The patient reportedly experienced mental confusion, muscle twitching, sweating, flushing, and ataxia. Until more is known, St. John’s wort should not be combined with trazodone except under expert clinical supervision.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
