Soy Protein for Weight Control

Some dieters say that soy protein provides a source of low-fat, cholesterol-free protein.

Protein is necessary for rebuilding tissue, which is especially important for bodybuilders. All types of protein provide the body with amino acids.

From an athletic point of view, soy is just another type of protein. Choosing soy protein over other types of protein adds variety to the protein choices available. However, because soy lowers cholesterol, it is an excellent choice for those also trying to lower their cholesterol levels.

Soy is a common ingredient in many meal replacements that are designed to provide a large amount of nutrients in a minimal amount of calories.

Animal and human studies have suggested that when soy is used as a source of dietary protein, it may have several biological effects on the body that might help with weight loss.¹ A preliminary study found that people trying to lose weight using a meal-replacement formula containing soy protein lost more weight than a group not using any formula.² However, controlled studies comparing soy protein with other protein sources in weight loss diets have not found any advantage of soy.^{3, 4, 5} When soy protein is used for other health benefits, typical daily intake is 20 grams per day or more.

Soy products and cooked soybeans are safe at a wide range of intakes. However, a small percentage of people have allergies to soybeans and thus should avoid soy products.

Soy isoflavones have been reported to reduce thyroid function in some people.⁶ A preliminary trial of soy supplementation among healthy Japanese, found that 30 grams (about one ounce) per day of soybeans for three months, led to a slight reduction in the hormone that stimulates the thyroid gland.⁷ Some participants complained of malaise, constipation, sleepiness, and even goiter. These symptoms resolved within a month of discontinuing soy supplements. However, a variety of soy products have been shown to either cause an increase in thyroid function⁸ or produce no change in thyroid function.⁹ The clinical importance of interactions between soy and thyroid function remains unclear. However, in infants with congenital hypothyroidism, soy formula must not be added, nor removed from the diet, without consultation with a physician, because ingestion of soy may interfere with the absorption of thyroid medication.¹⁰

Most research, including animal studies, report anticancer effects of soy extracts,¹¹ though occasional animal studies have reported cancer-enhancing effects.¹² The findings of several recent studies suggest that consuming soy might, under some circumstances, increase the risk of breast cancer. When ovaries have been removed from animals—a situation related to the condition of women who have had a total hysterectomy—dietary genistein has been reported to increase the proliferation of breast cancer cells.¹³ When pregnant rats were given genistein injections, their female offspring were reported to be at greater risk of breast cancer.¹⁴ Although premenopausal women have shown decreases in estrogen levels in response to soy,^{15, 16} pro-estrogenic effects have also been reported.¹⁷ When pre-menopausal women were given soy isoflavones, an increase in breast secretions resulted—an effect thought to elevate the risk of breast cancer.¹⁸ In yet another trial, healthy breast cells from women previously given soy supplements containing isoflavones showed an increase in proliferation rates—an effect that might also increase the risk of breast cancer.¹⁹

Of 154 healthy postmenopausal women who received 150 mg of soy isoflavones per day for five years, 3.9% developed an abnormal proliferation of the tissue that lines the uterus (endometrial hyperplasia). In contrast, none of 144 women who received a placebo developed uterine hyperplasia.²⁰ Although no case of uterine cancer was diagnosed during the study, endometrial hyperplasia is a potential forerunner of uterine cancer. The amount of isoflavones used in this study is two to three times as much as that used in many other studies. Nevertheless, the possibility exists that long-term use of isoflavones could cause uterine hyperplasia, and women taking isoflavones should be monitored appropriately by their doctor.

Some postmenopausal women taking the soy isoflavone genistein have experienced gastrointestinal side effects (abdominal pain, epigastric pain, dyspepsia, vomiting, or constipation).²¹

Soy contains a compound called phytic acid, which can interfere with mineral absorption.

Relatively large amounts of isoflavones are present in whole soybeans, roasted soy nuts, tofu, tempeh, soy milk, meat substitutes, soy flour, and some soy protein isolates. In addition, the isoflavones present in soy are available as supplements, in capsules or tablets.